- PhD inBiochemistry, Molecular Biology, Bio-engineering or equivalent
- Strong background in protein expression,purification and characterization
- Experiencein Cryo-EM and/or X-ray crystallography is mandatory
- Proficient in written and spoken English
- Strong organizational and interpersonalskills
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UAE Factory Workers Jobs - Abu Dhabi, United Arab Emirates - Media Factory
Description
At the VIB-VUB Center for Structural Biology(Vrije Universiteit Brussel / VIB), we are looking for a highlyqualified and motivated postdoctoral researcher with a strongbackground in Cryo-EM and/or X-ray crystallography, biochemistryand biophysics, and interested in biochemical andstructural studies on bacterial persistence
Project description:
Due to the development of resistance to antibiotics,bacterial infections are becoming more life-threatening every Inaddition to resistance, bacterial persistence offers an importantmeans to avoid clearance of Persisters are formed by phenotypicswitching to an antibiotic-tolerant state, rendering a small subsetof cells within an isogenic population capable of survivingantibiotic Within this ongoing research project we want to gainmore insight into the mechanisms of persistence by unravelling theassociated molecular pathways down to atomic resolution (Verstraeten et ; Cell 2015; Gkekas et Chem. 2017; Verstraeten et Micro2019). The project is part of an interdisciplinaryExcellence of Science program in collaborationwith the teams of Jan Michiels, R gis Hallez, Fran oise VanBambeke, Steven Ballet and J rg Within this consortium you will usesingle particle cryo-EM and X-ray crystallography, in combinationwith biophysical methods and enzyme kinetics, to gain insight inthe role of important persistence proteins and their Thisinformation will subsequently be used to intervene with theseproteins and processes to devise new potential therapeutic
For more information about the Vers es lab see
Requiredskills and experience:
Contact:
Please send applications (including CV,research experience, and at least two names and contact informationfor references) to:
Wim Vers es, VIB-VUB Centerfor Structural Biology, Vrije Universiteit Brussel, Pleinlaan 2,1050 Brussel - .
About CSB:
The VIB-VUB Center for Structural Biologyfocusses on the structure and dynamics of macromolecular complexesin health and Our multidisciplinary team of about 100 researchersis housed in new laboratory facilities and combines extensiveexpertise in structural biology (state of the art in-house cryo-EM,X-ray crystallography, NMR, SAXS, and atomic force microscopy),biophysics, enzymology and molecular